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KMID : 1134120060090010036
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Journal of Breast Cancer
2006 Volume.9 No. 1 p.36 ~ p.40
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Clinical Implication of Galectin-1 Expre- ssion in Human Breast Cancer
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Moon Hyeong-Gon
Park Jung-In
Lee Jong-Sil
Jeong Chi-Young
Ju Young-Tae
Jung Eun-Jung
Lee Young-Joon
Hong Soon-Chan
Choi Sang-Kyeong
Ha Woo-Song
Park Soon-Tae
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Abstract
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Purpose: Purpose: The role of different galectins in the pathogenesis of different types of malignancy is now being intensely investigated. In this study, authors investigated the level of galectin-1 expression in human breast cancer tissue to define its relationship to the tumor invasiveness and tumor progression.
Methods: Formalin-fixed, paraffin-embedded tissues from 79 randomly selected breast cancer patients were used to perform immunohistochemical staining for galectin-1. The primary antibody was diluted mouse monoclonal antibody against galectin-1. The staining results were then interpreted by an experienced pathologist, and the results were compared between the groups having different pathologic variables.
Results: In breast cancer patients, galectin-1 was diversely expressed in the cancer tissue. Galectin-1 was expressed in both cancer cells and cancer-associated stromal cells. The levels of galectin-1 expression in cancer-associated stromal cells were higher in patients with invasive carcinoma (p = 0.001), in patients with advanced T stages (p = 0.007), and in patients with advanced TNM stages (p = 0.007). The galectin-1 expression in cancer-associated stromal cells was also higher in patients with lymph node metastasis and advanced N stages, but did not reach a statistically significant level. The galectin-1 expression in cancer cell did not have any correlation with pathologic variables.
Conclusion: This is the first study that has demonstrated the relationship of galectin-1 expression with the tumor invasiveness and tumor progression in human breast cancer. Further large-scaled studies are needed to define the prognostic value of galectin-1 in breast cancer patients, and the exact role of galectin-1 should be investigated more thoroughly. (J Breast Cancer 2006;9: 36-40)
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KEYWORD
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Breastneoplasms, Galectins, Neoplasm invasiveness, Immunohistochemistry
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